Adam Schefter reports that 49ers QB Jimmy Garoppolo has been ruled out for Week 5 due to the calf injury he suffered in Week 4 against the Seahawks.
Fantasy Impact: With Garoppolo ruled out for Sunday’s matchup with the Cardinals, this could be the changing of the guard in San Francisco. The Arizona D/ST ranks in the bottom of the NFL against in rushing defense, and Lance could very well take the reigns and “run” with them.
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